PPMI Completed & Ongoing Biologic Analyses

	Principal Investigator	Organization	Project Title	Data Availability	Analyte	Matrix	Included Enrollment Cohorts	Subcategories included	Visit(s)	Project ID	Notes
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1	Andrew Singleton, PhD	NIA	APOE4 Genotyping​	Currently available	APOE4 genotyping​	DNA from whole blood	Healthy Control Parkinson Disease SWEDD (legacy)	N/A	Baseline	104
2	Clemens Scherzer, MD	Harvard	Evaluation of PD-linked Transcripts in PPMI	Currently available	aSyn transcripts	RNA from whole blood	Healthy Control Parkinson Disease	N/A	Baseline	105
3	Andrew Singleton, PhD	NIA	Selected Genetic Variants Genotyped Using NeuroX Array	Currently available	NeuroX genotyping	DNA from whole blood	Healthy Control Parkinson Disease Prodromal SWEDD (legacy)	Genetic subjects	Baseline	106, 107
4	Andrew Singleton, PhD	NIA	Immunochip Genotyping on DNA Samples from PPMI	Currently available	Immunochip genotyping​	DNA from whole blood	Healthy Control Parkinson Disease SWEDD (legacy)	N/A	Baseline	108
5	Les Shaw, PhD	UPenn	A-beta 1-42, t-tau and p-tau 181 Measurements in PPMI CSF Samples using xMAP/Luminex Multiplex Immunoassay & Roche Elecsys	Currently available	Aβ, tau, & p-tau181 ​	CSF	Healthy Control Parkinson Disease Prodromal SWEDD (legacy)	Genetic subjects	Baseline, 6, 12, 24, 36 months	110, 125	Innogentics: PD, HC, & SWEDD through yr 1; Elecsys: PD, HC, & SWEDD through yr 3, prodromal & genetic through yr 1
6	Alice Chen-Plotkin, MD, MSc	UPenn	Plasma Apolipoprotein A1 Level as a Biomarker in Parkinson’s Disease	Currently available	ApoA1 & EGF​	Plasma	Healthy Control Parkinson Disease	N/A	Baseline, 6, 12 months	112
7	Maria Teresa Pellecchia, PhD	University of Salerno	Insulin-like Growth Factor-1 as a Biomarker of Early Cognitive Impairment in PD	Currently available	IGF-1	Serum	Healthy Control Parkinson Disease	N/A	Baseline	113
8	Judith Potashkin, PhD	Rosalind & Franklin University	Whole blood RNA Biomarkers of PD	Currently available	mRNA transcripts	RNA from whole blood	Healthy Control Parkinson Disease	N/A	Baseline	114
9	Matthew Farrer, PhD	University of BC	Clinical, Imaging, & Plasma & CSF Correlates of aSyn Genomic Variability	Currently available	SNCA genotyping​	DNA from whole blood	Healthy Control Parkinson Disease	N/A	Baseline	115
10	Andrew Singleton, PhD	NIA	Exome Sequencing of PPMI samples	Currently available	Whole exome sequencing	DNA from whole blood	Healthy Control Parkinson Disease SWEDD (legacy)	N/A	Baseline	116
11	Andrew Singleton, PhD	NIA	Whole Genome Sequencing & Analysis of PPMI Prodromal & Genetic Cohorts & Genetic Registry​	Currently available	Whole genome sequencing	DNA from whole blood	Healthy Control Parkinson Disease Prodromal SWEDD (legacy)	Genetic subjects	Baseline	118
12	Martin Rabey, MD	BioShai Ltd.	Validation of a blood-based Gene Expression Assay for Early Diagnosis & Monitoring Disease	Currently available	mRNA transcripts	RNA from whole blood	Healthy Control Parkinson Disease SWEDD (legacy)	N/A	Baseline, 12, 24, 36 months	119
13	Dena Hernandez, PhD	NIA​	DNA Methylation in PPMI	Currently available	Dna methylation	DNA from whole blood	Healthy Control Parkinson Disease SWEDD (legacy)	N/A	Baseline	120
14	Thomas Kremer, PhD; Kristen Taylor, PhD	Roche	CSF Neurotransmitter Metabolites as Promising Diagnostic & Disease Severity Biomarkers in Early-Stage PD Patients​	Currently available	Catecholamines​	CSF	Healthy Control Parkinson Disease	N/A	Baseline, 12, 24 months	122
15	Dwight German, PhD	UT Southwestern	Blood Biomarker for PD	Currently available	PD2 peptoid	Serum	Healthy Control Parkinson Disease	N/A	Baseline	123
16	Peggy Taylor, PhD	BioLegend	aSyn Measurements in Longitudinal CSF Samples From De Novo, PD, CT, SWEDD, Prodromal, & Genetic Cohorts​	Currently available	total aSyn, hemoglobin, & total protein	CSF	Healthy Control Parkinson Disease Prodromal SWEDD (legacy)	Genetic subjects	Baseline, 6, 12, 24, 36 months	124	PD, HC, SWEDD through yr 3, prodromal & genetic through yr 1
17	Andrew Singleton, PhD	NIA	GBA Sequencing	Currently available	GBA sequencing	DNA from whole blood	Healthy Control Parkinson Disease SWEDD (legacy)	N/A	Baseline	126
18	Satpal Virdee, PhD	University of Dundee​	Profiling PINK1-Parkin Functionality in Patient Fibroblasts Using Chemical Probes	Currently available	PINK1	Fibroblasts	Healthy Control Parkinson Disease	N/A	N/A	127
19	Xinnan Wang, PhD	Stanford University​	Miro, a Biomarker for Parkinson’s Disease	Currently available	Miro	Fibroblasts iPSCs	Healthy Control Parkinson Disease Prodromal	Genetic subjects	N/A	129
20	Gavin Hudson, PhD	Newcastle University	The Role of Cell-Free Mitochondrial DNA in Neurodegenerative Disease	Currently available	Cell-free mitochondrial Dna	CSF	Healthy Control Parkinson Disease	N/A	Baseline, 36 months	130
21	Kendall Van Keuren-Jensen, PhD	TGen Foundation	RNAseq in PPMI	Currently available (summary files, raw data for cloud transfer, & data explorer)​	mRNA& miRNA sequencing​	RNA from whole blood	Healthy Control Parkinson Disease Prodromal SWEDD (legacy)	Genetic subjects	Baselilne, 6, 12, 24, 36 months	131, 133	Data available as summary files, raw data for cloud transfer, & data explorer
22	Pablo Sardi, PhD	Sanofi	GBA-Related Biomarkers in Parkinson's Disease	Currently available	GCase activity & sphingolipids​	CSF Plasma Whole blood	Healthy Control Parkinson Disease SWEDD (legacy)	N/A	Baseline, 12, 24, 36 months	132, 135
23	Nilima Prakash, PhD	Hamm-Lippstadt University of Applied Sciences​	Altered Calcium Activity Patterns in Developing Dopaminergic Neurons from PD Patients as an Early Indicator of Disease Predisposition or Progression	Currently available	Calcium activity	Fibroblasts iPSCs	Healthy Control Parkinson Disease	N/A	N/A	136
24	Rachit Bakshi, PhD	MGH/MIND​	Urate & Nrf2 Pathway Effects on Mutant LRRK2 Toxicity in iPSC-Derived DA Neurons	Currently available	Urate & Nrf2​	iPSCs	Healthy Control Parkinson Disease Prodromal	LRRK2 subjects	N/A	137
25	Travis Dunckley, PhD; Paula Desplats, PhD	Arizona State University; UCSD	Comprehensive Methylation Profiling of the PPMI Cohort​	Currently available	Methylation profiling​	DNA from whole blood	Healthy Control Parkinson Disease Prodromal	LRRK2 subjects	Baseline, 12, 24, 36 months	140
26	Nic Dzamko, PhD	University of Sydney​	Inflammatory phenotypes in differentiated human LRRK2 & GBA mutation IPS cell lines	Currently available	Inflammation/​lysosomal function	iPSCs	Healthy Control Parkinson Disease Prodromal	GBA & LRRK2 subjects	N/A	141
27	Danielle Graham, PhD; Brit Mollenhauer, MD	Biogen; Paracelsus EleN/A Klinik	Investigation of Neurofilament Light Chain in Serum from the PPMI Cohorts as Progression Marker for PD​	Currently available	Neurofilament Light (NFL)​	Serum	Healthy Control Parkinson Disease Prodromal	Genetic subjects	PD & HC: Baseline, 6, 12, 24, 36, 60 months; Prodromal & genetic cohorts: Baseline, 6, 12, 24, 36 months	144
28	Kalpana Merchant, PhD	TransThera	Do Urinary BMP Levels Change with Disease Progression in Idiopathic & Genetic PD?	Currently available	BMP	Urine	Healthy Control Parkinson Disease Prodromal	GBA & LRRK2 subjects	PD, HC, & GBA: Baseline only; LRRK2: Baseline, 12, 24 months	145
29	Dimitri Krainc, MD	Northwestern University	Convergence of LRRK2 & GBA1 in the Pathogenesis of Parkinson’s Disease	Currently available	GCase activity in dopaminergic neurons​	iPSCs	Healthy Control Parkinson Disease	LRRK2 subjects	N/A	148
30	Matt LaVoie, PhD	Brigham & Women’s, Harvard​	Role of LRRK2 in Gcase-mediated Alterations in Lysosome Functions & aSyn Metabolism	Currently available	LRRK2 at lysosomes	iPSCs	Parkinson Disease	GBA subjects	N/A	149
31	Andy Singleton, PhD	NIA	The Foundational Data Initiative	Currently available	Transcriptional activity, gene regulation, epigenetics​	iPSCs	Healthy Control Parkinson Disease Prodromal SWEDD (legacy)	Genetic subjects	N/A	150	Data portal under development
32	Fiona Elwood, PhD	Novartis	Identification of Proteins & Protein Networks in Human CSF That Differentiate Within PD Patients​	Currently available	SomaLogic collaboration (with Merck & Novartis)​	CSF	Healthy Control Parkinson Disease Prodromal	Genetic subjects	Baseline	151
33	Richard Batrla-Utermann, PhD	Roche	Roche NeuroTool Kit	Currently available	Roche Elecsys NeuroTool Kit (aSyn, GFAP, IL-6, S100b, neurogranin, NFL, sTREM2, YKL40)​	CSF	Healthy Control Parkinson Disease	N/A	Baseline, 6, 12, 24, 36, 48 months	152
34	Thomas Schwarz, PhD	Boston Children’s Hospital​	Mitochondrial Transport Defects as a Potential Biomarker in Patient-derived Cells	Currently available	Mitochondrial transport​	iPSCs	Healthy Control Parkinson Disease	Genetic subjects	N/A	153
35	Ellen Sidransky, MD​	NIH	Development of Novel TRPML1 Activator for Treatment of PD	Data unavailable	Calcium channel agonists	iPSCs	Healthy Control Parkinson Disease	N/A	N/A	154
36	Claudio Soto, PhD	Amprion	Monitoring the Progression & Pre-clinical Diagnosis of PD by Detection of aSyn Oligomers in CSF Using the PMCA Assay	Currently available	aSyn seeding (PMCA)- Round Robin & Phase 2​	CSF	Healthy Control Parkinson Disease Prodromal SWEDD (legacy)	Genetic subjects	Phase 1: Baseline, 36, mo; Phase 2: PD, HC, SWEDD at Baseline, prodromals at all visits, SNCA at all visits, LRRK2/GBA PD at Baseline and NMC at Baseline & all visits for phenoconverted	155	Phase 1 (bl & 36 months) PD, CT, SWEDD currently available; remaining data expected EOY
37	Aaron Day Williams, PhD	Flagship 60​	Investigation of Phenotypic Differences Between Familial PD, Idiopathic PD and Controls in Patient-derived iPSCs	Currently available	Phenotyping	iPSCs	Healthy Control Parkinson Disease Prodromal	LRRK2 subjects	N/A	156
38	Marlene Jacobson, PhD	University of Dundee​	Investigating the Effect of Small Molecules to Rescue Lysosomal & GBA-1 Deficiencies in GBA-PD	Currently available	Lysosomal rescue​	Fibroblasts	Healthy Control Parkinson Disease	N/A	N/A	158
39	Les Shaw, PhD	UPenn	PPMI CSF A-beta42, t-tau, and p-tau 181 Analysis 2019	Currently available	Aβ, tau, & p-tau181 ​	CSF	Healthy Control Parkinson Disease Prodromal SWEDD (legacy)	Genetic subjects	Baseline, 6, 12, 24, 36, 48, 60, 72, 84, 96, 108 months	159	75 Bridging study & 2,000+ remaining PPMI samples not yet aN/Alyzed from previous efforts
40	Sulev Koks, MD, PhD	Murdoch University	Association of Repetitive Elements with Parkinson's Disease Risk and Progression in the PPMI Cohort	Currently available	Tandem repeats	DNA from whole blood	Healthy Control Parkinson Disease	N/A	Baseline	160
41	Maximiliano Gutierrez, PhD	Francis Crick Institute​	The Role of LRRK2 Kinase Activity in Human Macrophage Function	Currently available	LRRK2 kinase activity	iPSCs	Parkinson Disease	LRRK2 subjects	N/A	161
42	Liana Rosenthal, MD	John Hopkins	Is Poly ADP-ribose in the CSF a Biomarker for PD Diagnosis or Progression?​	Currently available	Poly ADP-ribose​	CSF	Healthy Control Parkinson Disease	N/A	Baseline, 6, 12, 18, 24, 36,48, 60 months	165
43	Eleanor Coffey, PhD	Turku Centre for Biotechnology​	PD Signature Validation Project Related to "Improving Patient Diagnosis, Stratification & Disease Monitoring in PD	Currently available	Protein handling	PBMCs	Healthy Control Parkinson Disease Prodromal	Genetic subjects	3 longitudinal timepoints	170
44	Cornelis Blauwendraat, PhD	NIA	Long read DNA sequencing of the PPMI cohort​	Expected Q1 2025	Long read Dna sequencing​	DNA from whole blood	Healthy Control Parkinson Disease Prodromal SWEDD (legacy)	Genetic subjects	Baseline	171
45	Byron Caughey, PhD	NIH	aSyn Seeding Assay Round Robin- NIH​	Currently available	aSyn seeding​ (RT-QuIC)- Round Robin	CSF	Healthy Control Parkinson Disease SWEDD (legacy)	N/A	Baseline, 36 months	172
46	Roland Heym, PhD	Abbvie	Evaluation of Seeding-competent aSyn in the CSF as a Biomarker for Parkinson’s Disease	Currently available	aSyn seeding​ (RT-QuIC)- Round Robin	CSF	Healthy Control Parkinson Disease SWEDD (legacy)	N/A	Baseline, 36 months	173
47	Dong-Gyu Jo, PhD	Sungkyunkwan University​	Study for the Propagation of aSyn (Screening the Propagation Relative Genes)	Expected Q1 2025	aSyn propagation	iPSCs	Healthy Control Parkinson Disease	GBA & LRRK2 subjects	N/A	174
48	Kirsten Taylor, PhD	Roche	aSyn PMCA Assay at Amprion	Currently available	aSyn seeding​ (PMCA in leftover samples)	CSF	Healthy Control Parkinson Disease	N/A	Baseline, 12, 24 months	176
49	Jennifer Van Eyk, PhD	Cedars-Sinai	Post-Translational Modification & Protein Quantification of Plasma & CSF	Currently available	Unbiased proteomics (DIA MS, AMP PD)	CSF Plasma	Healthy Control Parkinson Disease	N/A	Baseline & 3 longitudinal timepoints	177
50	Kimberly Billingsley, PhD	NIH	Identifying the Role of Structural Variants in PD	Expected Q2 2025	Structural variants	DNA from whole blood	Healthy Control Parkinson Disease	N/A	Various	179
51	Michael Schwarzschild, PhD	MGH & Denali	Metabolomic Analysis of Penetrance, Prognosis, & Tracking Biomarkers of LRRK2 PD	Plasma available; CSF Expected Q1 2025	Metabolomics	CSF Plasma	Healthy Control Parkinson Disease Prodromal	GBA & LRRK2 subjects	Plasma: Baseline,12, 24 months; CSF: Baseline only	180, 215
52	Marion Buckwalter, PhD	Stanford	Adaptive Immune Markers for Predicting Cognitive Decline in PD	Currently available	Immune profiling	CSF Plasma	Healthy Control Parkinson Disease	N/A	Baseline, 48 months	181
53	Shawn Ritchie, PhD	Med-Life Discoveries	Validation of Plasmalogen Augmentation as a Viable Drug Target in PD​	Currently available	Plasmalogen​	Plasma	Healthy Control Parkinson Disease SWEDD (legacy)	Genetic subjects	Baseline	182
54	Sebastian Virreira Winter, PhD	OmicEra​	Targeted & Untargeted MS Based Proteomics of Urine in PD	Currently available	Urine proteomics	Urine	Healthy Control Parkinson Disease Prodromal	GBA & LRRK2 subjects	PD, HC, & GBA: Baseline only; LRRK2: Baseline, 12, 24 months	190
55	Deniz Kirik, MD, PhD	University of Sydney	An in vivo approach to elucidate the pathobiology of PD-associated genes using human diseased neurons	Currently available	Whole genome sequencing on midbrain and cortical neurons and astrocytes	Fibroblasts iPSCs	Healthy Control Parkinson Disease	N/A	N/A	193
56	Alejandro Pezzulo, MD	University of Iowa	Multidisciplinary Analysis of Metabolic Dysregulation in Parkinson's Disease	Expected Q1 2025	Metabolic profiling	Fibroblasts	Healthy Control Parkinson Disease	N/A	N/A	194
57	Christos Proukakis, MD, PhD	University College London	Detection of GBA Mutations by Combination of Illumina & nanopore Sequencing​	Currently available	Long read GBA sequencing	DNA from whole blood	Parkinson Disease Prodromal	GBA subjects	Various	195
58	Eline Appelmans, PhD	FNIH	Targeted Proteomics in AMP PD	Currently available	Targeted proteomics (O-Link Explore 1536, AMP PD)​	CSF Plasma	Healthy Control Parkinson Disease	N/A	Baseline & 3 longitudinal timepoints	196
59	Xiqun Chen, MD, PhD	Mass General Hospital​	From Cancer Associations to Altered Immunity in the Pathogenesis of Parkinson’s Disease	Expected Q3 2025	Inflammation	iPSCs	Healthy Control Parkinson Disease	LRRK2 subjects	N/A	197
60	Erika Holzbaur, PhD	UPenn​	Investigating Mitochondrial Trafficking Deficits Across PD Models	Expected Q1 2025	Mitochondrial trafficking​	iPSCs	Healthy Control	Genetic subjects	N/A	198
61	Magdalene Moran, PhD	Caraway Therapeutics​	Developing TMEM175 Activators as Therapeutics for PD	Currently available	TMEM175 activators​	iPSCs	Parkinson Disease	GBA subjects	N/A	199
62	Adam Mamais, PhD	University of Florida​	Converging Pathways of LRRK2 & PINK1 Biology Impacting Iron Homeostasis & Mitochondrial Function	Currently available	Iron & mitochondrial homeostasis​	iPSCs	Healthy Control Parkinson Disease	LRRK2 subjects	N/A	202
63	Massimiliano Bianchi, PhD	Ulysses Neuroscience Ltd	Validation of microtubule dynamics as a novel target in Parkinson’s disease	Expected Q2 2025	Microtubule dynamics in midbrain-like 3D organoid cultures	iPSCs	Healthy Control Parkinson Disease Prodromal	iPD, Hyposmic	N/A	203
64	George Tofaris, MD, PhD	University of Oxford	Serum Neuronal Exosomes as Predictive or Dynamic Biomarkers in PD	Partially available	Neuronal exosomes (aSyn)​	Serum	Healthy Control Parkinson Disease Prodromal	GBA, LRRK2, RBD, Hyposmic	Baseline, 3, 6 Months	204
65	Hiroaki Kaku, PhD	Western Michigan University​	The Role of FAIM in Parkinson’s Disease​	Expected Q2 2025	FAIM	iPSCs	Parkinson Disease	GBA & SNCA subjects	N/A	206
66	Karen MacLeod, Claudio Soto, PhD	Amprion	Development and Optimization of Semi-Quantitate PMCA for Analysis of Soluble ASYN Aggregates in CSF in Amprion's Clinical Laboratory	Currently available	aSyn seeding (PMCA)	CSF	Healthy Control Parkinson Disease	N/A	Various	207	Used warmed CSF from various visits
67	Gallen Triana-Baltzer, PhD	Janssen	ptau 217 in the Parkinson Progression Marker Initiative (PPMI)	Expected Q2 2025	Tau	Plasma	Parkinson Disease	LRRK2 subjects	Baseline	208
68	Bastian Zinnhardt, PhD	Roche	Identification of NLRP3 Inflammasome-related biomarkers in PPMI CSF Samples	Currently available	IL1B	CSF	Healthy Control Parkinson Disease	N/A	Baseline, 12, 24 Months	209
69	Anumantha Kanthasamy, PhD	Iowa State University	PPMI a-Syn Skin Seeding Assay	Currently available	aSyn seeding​ (RT-QuIC)- Round Robin	Skin	Healthy Control Parkinson Disease	N/A	Baseline	211
70	Bahareh Ajami, PhD; Dario Alessi, PhD	Oregon Health & Science University, University of Dundee	Investigating the influence of genetic risk factors of PD on peripheral immune cells to identify potential biomarkers for prediction of conversion of non-manifesting to manifesting carriers.	Partially available	Immune Cell Phenotyping, transcriptomics and proteomics”	PBMCs Plasma	Parkinson Disease	N/A	N/A	213
71	Khalil Ramadi, PhD	New York University	Neural Chemical Delivery System for Treatment of Parkinson's Disease	Expected Q1 2025	Dopamine neuronal cell survival, engraftment, and integration	Fibroblasts iPSCs	Healthy Control Parkinson Disease	N/A	N/A	216
72	Mark Cookson, PhD	NIH	Lysosomal damage and LRRK2 activation	Expected Q1 2025	LRRK2 activity and lysosomal health	iPSCs	Healthy Control Parkinson Disease	LRRK2	N/A	218
73	Julian Sefrin, PhD	Abbvie	Evaluation of TMPRSS5 (Spinesin) in the CSF as a potential biomarker for early Parkinson’s disease diagnosis and progression	Currently available	Spinesin	CSF	Parkinson Disease Prodromal	Phenoconverters, Short Duration iPD, Genetic Subjects, Hyposmic, RBD	Baseline, 6, 12, 24, 36, 48, 60 Months	219
74	Omar Mabrouk, PhD	Biogen	CSF total LRRK2 measurements as a Biomarker in genetic PD	Partially Available	LRRK2	CSF	Healthy Control Parkinson Disease Prodromal	GBA & LRRK2 subjects	Baseline, 24 Months	221
75	Aparna Vasanthakumar, PhD	Abbvie	O-Link in PPMI	Currently Available	Targeted proteomics	CSF Plasma		N/A	Baseline, 6, 12, 24, 36, 48, 60 months	222
76	Anthony Schapira, MD	UCL Medical School	The genome-microbiome axis in the cause of Parkinson disease: Mechanistic insights and therapeutic implications from experimental models and a genetically stratified patient population	Expected Q3 2025	Assessing PD phenotypes in enteric neurons, dopaminergic neurons, astrocytes, microglia	iPSCs	Healthy Control Parkinson Disease	N/A	N/A	223
77	Céline Galvagnion, PhD	University of Copenhagen	Understanding selective neuronal vulnerability in the context of Parkinson's Disease	Expected Q2 2026	Proteomics and lipidomics in dopamine and cortical neurons	iPSCs	Healthy Control Parkinson Disease	LRRK2, iPD	N/A	224
78	Susanna Narkilahti, PhD	University of Tampere	Electrophysiological Phenotype Characterization of iPSC-derived Neuronal Cells with PD-linked LRRK2 Mutations during Network Formation and Alpha-Synuclein Seeded Aggregation	Expected Q1 2025	electrophysiological phenotype	iPSCs	Healthy Control Parkinson Disease Prodromal	LRRK2 G2019S, LRRK2 R1441G	N/A	227
79	Mark Cookson, PhD	NIH	FOUNDIN[mu]- a microglial resource for PPMI lines	Expected Q1 2025	ATACseq and RNAseq in microglia	iPSCs	Healthy Control Parkinson Disease	N/A	N/A	228
80	Sonia Gandhi, PhD, MD	University College London	Defining mechanisms in neurons and oligodendrocytes that drive progression in Parkinson’s	Expected Q3 2025	High content imaging, transcriptomics in dopamine neurons and oligodendrocytes	iPSCs	Healthy Control Parkinson Disease Prodromal	iPD, SNCA (A53T), Hyposmic, RBD	N/A	229
81	Rhalena Thomas, PhD	McGill University	A pipeline for massive multiplexing of iPSC-derived dopaminergic neurons and microglia for cohort-scale transcriptomics in PD	Expected Q1 2025	scRNAseq profiling of pooled iPSC dervied neurons and microglia	iPSCs	Healthy Control Parkinson Disease Prodromal	iPD, GBA N370S, LRRK2 G2019S, LRRK2 R1441G, SNCA (A53T), Hyposmic	N/A	230
82	Lezanne Ooi, PhD	University of Wollongong	Metabolic phenotyping in PD dopaminergic neurons and neuronal-glial co-cultures using high-throughput single-cell metabolomics and lipidomics	Expected Q3 2025	Single cell metabolomics and lipidomics in dopamine neurons, Astrocytes, Microglia	iPSCs	Healthy Control Parkinson Disease Prodromal	iPD, GBA N370S, LRRK2 G2019S, LRRK2 R1441G, SNCA (A53T), Hyposmic	N/A	231
83	Gist Croft, PhD	The New York Stem Cell Foundation	A cohort-wide resource of transcriptomic and morphological phenotypes in defined neural cell types	Expected Q1 2025	RNAseq and cell painting in NGN2 neurons and cortical excitatory neurons	iPSCs	Healthy Control Parkinson Disease Prodromal	iPD, GBA N370S, LRRK2 G2019S, LRRK2 R1441G, SNCA (A53T), Hyposmic, RBD	N/A	232
84	Laurent Roybon, PhD	Van Andel Research Institute	Uncovering proteomic alterations in Parkinson’s disease using patient-specific iPSC-derived brain cells	Expected Q1 2025	Proteomics in neurons, astrocytes and oligodendrocytes	iPSCs	Healthy Control Parkinson Disease Prodromal	iPD, GBA N370S, LRRK2 G2019S, LRRK2 R1441G, SNCA (A53T), Hyposmic	N/A	233
85	Laurent Roybon, PhD	Van Andel Research Institute	Omic-based analyses of PD iPSC-derived brain cells	Expected Q1 2025	Multi-omics characterization of diverse cell types (DA neurons & cortical neurons, astrocytes, oligodendrocyte, and microglia)	iPSCs	Healthy Control Parkinson Disease Prodromal	iPD, GBA N370S, LRRK2 G2019S, LRRK2 R1441G, SNCA (A53T), Hyposmic	N/A	234
86	Lalitha Madhavan, PhD, MD	University of Arizona	Deep phenotyping of PD relevant mitochondrial and autophagic mechanisms in human iPSC-derived neural cells	Expected Q1 2025	Mitochondrial and autophagic phenotypes/alpha-synuclein	iPSCs	Healthy Control Parkinson Disease	iPD, HC	N/A	235
87	Souvik Modi, PhD	ESYA Labs	ESYA PD360: A multi-parametric platform for establishing a novel lysosome-based biomarker and identifying therapeutic interventions for Parkinson’s Disease	Currently available	RNAseq, pH, calcium and autophagy analyses in fibroblasts	Fibroblasts	Healthy Control Parkinson Disease	iPD	N/A	236
88	Luis Concha, PhD	Amprion	Analysis of CSF samples	Ongoing availability	Alpha-Synuclein Seeds	CSF	Healthy Control Parkinson Disease Prodromal	N/A	Baseline, 6, 12 Months	237
89	Daniel Ysselstein, PhD	Vanqua Bio	Glucocerebrosidase Activation as a Therapeutic Strategy for Parkinson’s Disease	Expected Q1 2025	Longitudinal assessment of GCase activity, insoluble aSyn, sphingolipids, and lysosomal dysfunction in DA neurons	iPSCs	Healthy Control Parkinson Disease	GBA, iPD	N/A	239
90	Nick Hertz, PhD	Mitokinin	Assessing pS65 Ubiquitin levels in biofluids as a biomarker for Parkinson's Disease	Currently available	pS65Ub	CSF Plasma	Healthy Control Parkinson Disease Prodromal	N/A	Baseline, 6, 12, 24, 36, 48, 60 months	240
91	Hilde Nilsen, PhD	Oslo University Hospital	Mitochondrial Transcription regulation via Base Excision Repair	Expected Q1 2026	NTHL1	iPSCs	Healthy Control Parkinson Disease Prodromal	SNCA	N/A	241
92	Luis Concha, PhD	Amprion	Evaluation of αSyn seed levels in prodromal cases by means of a semi-quantitative seed amplification assay & Validation of Clinical Accuracy of the Rapid Qualitative αSynuclein Seed Amplification Assay in the Amprion Clinical Laboratory	Expected Q1 2025	Alpha-Synuclein Seeds	CSF	Healthy Control Parkinson Disease SWEDD (legacy)	N/A	24-hour samples	242
93	Michael Schwarzchild, PhD, MD	Massachusetts General Hospital	Metabolomic Analysis of Penetrance, Prognosis and Tracking Biomarkers of LRRK2 PD	Expected Q1 2025	B12	CSF Plasma	Healthy Control Parkinson Disease Prodromal	GBA & LRRK2 subjects	Plasma: Baseline,12, 24 months; CSF: Baseline only	243
94	David Sulzer, PhD	Research Foundation for Mental Hygiene, Inc.	Adaptive immunity in the etiology and progression of Parkinson’s disease	Currently available	aSyn-reactive T cells	PBMCs	Healthy Control Parkinson Disease Prodromal	N/A	N/A	245
95	Saranna Fanning, PhD	Brigham & Women's Hospital, Inc.	Advancing Clinical Relevance of a Lipase as a Therapeutic Target for Parkinson’s Disease in PPMI Subject Derived iPSCs	Expected Q1 2026	Monoacylglycerol lipase (MGL)	Fibroblasts iPSCs	Healthy Control Parkinson Disease	SNCA,GBA	N/A	247
96	Ivan Martinez-Valbuena, PhD	University of Toronto	Developing a standardized skin-based alpha-synuclein seeding amplification assay for the diagnosis of Parkinson’s disease	Currently available	SAA	Tissue	Healthy Control Parkinson Disease	N/A	BL, 6, 48,	248
97	Nobutaka Hattori, MD, PhD	Juntendo	Validation of a Serum Synuclein Seed Amplification Assay IP/SAA in PPMI	Expected Q2 2025	SAA	Serum	Parkinson Disease	N/A	Baseline, 6, 12 Months	249
98	Joanne Trinh, PhD	Institute of Neurogenetics, Luebeck	Interaction of the environment and somatic modifiers in mitochondrial genes on disease penetrance	Expected Q3 2027	Mitochondrial DNA variations	DNA from whole blood	Healthy Control Parkinson Disease Prodromal SWEDD (legacy)	N/A	SC and Baseline	250
99	Bastian Zinnhardt, PhD	Roche	Linking inflammasome activation biomarkers with general inflammation and neurodegeneration markers	Expected Q1 2025		CSF	Healthy Control Parkinson Disease	N/A	Baseline, 12, 24, 48 months	253
100	Maximilliano Gutierrez, PhD	The Francis Crick Institute	The impact of the LRRK2 G2019S mutation on lysosomal function in macrophages	Expected Q1 2026	LRRK2 kinase activity	iPSCs	Parkinson Disease	N/A	N/A	254
101	Sri Ramulu, Pullagura, PhD	FNIH	Identification of disease progression-predictive autoantibody biomarker signatures in the plasma of PD patients	Expected Q1 2025		Plasma	Healthy Control Parkinson Disease	N/A	Healthy Control: Baseline and 48 months; PD: 3 visits Baseline to 48 months	256
102	Sarah Huntwork-Rodriguez, PhD	Denali	Metabolomic Analysis of Penetrance, Prognosis and Tracking Biomarkers of LRRK2 PD	Expected Q1 2025	Polyamines	CSF Plasma	Healthy Control Parkinson Disease Prodromal	GBA & LRRK2 subjects	Plasma: Baseline,12, 24 months; CSF: Baseline only	261
103	Roland Heym, PhD	AbbVie	Evaluation of pathological alpha-synuclein in skin biopsies as potential biomarker for Parkinson’s disease	Partially available	aSyn seeds (by SAA) and pS129-aSyn (by LBA)	Skin	Healthy Control Parkinson Disease Prodromal	iPD, HC	Baseline, 36 months, 72 months, >72 months	262, 301, 302
104	Omar Mabrouk, PhD	Biogen	Surveying endo-lysosomal function in PD subtypes using an LC-MS-based 12-plex in CSF	Expected Q4 2025	LAMP1, LAMP2, Cathepsins B, D, F, L, S GM2A, GBA, GPNMB, Ubiquitin, LC3	CSF	Healthy Control Parkinson Disease	GBA & LRRK2 subjects	Baseline, 12, and 24 months	264
105	Pier Giorgio Mastroberardino, PhD	University of L'Aquila	Alterations in DNA repair mechanisms in PD nervous system cells and their correlation with clinical variables	Expected Q1 2027	DNA damage markers	iPSCs	Healthy Control Parkinson Disease	N/A	N/A	267
106	David Vocadlo, PhD	Simon Fraser University	Generation of isogenic control lines for the iPSCs derived from Parkinson’s Disease patients carrying GBA or LRRK2 mutations and assessment of GCase activity	Expected Q4 2026	GCase activity	iPSCs	Parkinson Disease	LRRK2, GBA, GBA non-manifesting carriers	N/A	268
107	Philip Milliken, PhD	Galvani Bioelectronics	Splenic nerve stimulation to reduce inflammation driven Parkinson’s progression and LRRK2 mutation-driven Parkinson’s risk	Expected Q3 2025	Cytokines, including TNFalpha	iPSCs	Healthy Control Parkinson Disease	LRRK2	N/A	269
108	Julian Sefrin, PhD	AbbVie	Evaluation of polyamines as disease and progression biomarkers in the CSF of Parkinson´s disease patients	Expected Q1 2025	Polyamines	CSF	Healthy Control Parkinson Disease Prodromal	N/A	Baseline, 6, 12, 24, 36, 48, 60 months	273
109	Roland Heym, PhD	AbbVie	Validation of monoclonal antibody-based ligand binding assay for DDC as potential diagnostic biomarker for Parkinson’s disease	Currently available	DOPA decarboxylase (DDC)	CSF	Healthy Control Parkinson Disease SWEDD (legacy)	N/A	Healthy Control and PD: Baseline and 36 months; SWEDD: Baseline	274
110	Brit Mollenhauer, MD	University of Goettingen	Multiplex proteome analysis for NSD in PPMI to identify progression biomarkers for early disease therapeutic trials	Expected Q2 2025	Targeted Proteomics (O-link)	CSF	Healthy Control Parkinson Disease Prodromal	N/A	Baseline, Visit 08	277
111	Benoit Lehallier, PhD	Alkahest	CHRONOS-PD: the longitudinal molecular time machine of Parkinson’s Disease	Expected Q2 2026	Unbiased proteomics (Somalogics, O-link, MS and NULISA)	Plasma	Healthy Control Parkinson Disease	N/A	N/A	280
112	Brit Mollenhauer, MD	University of Goettingen	Quantification of previously identified Dopa Decarboxylase, Midkine and Neurofilament light Chain as progression biomarker in stage 2/3 Parkinson’s disease to support prevention trials	Expected Q3 2025	DDC	CSF Plasma	Healthy Control Parkinson Disease Prodromal	N/A	Baseline, Visits 04 and 08	281
113	Nicholas Ashton, PhD	Banner Health	NuLISAseq proteomics investigation (Inflammation & CSF panels) of PPMI CSF samples (NSD & non-NSD)	Expected Q4 2025	NFL and GFAP (plasma); AB40/42 and p-tau 181 in CSF	CSF	Healthy Control Parkinson Disease Prodromal	N/A	BL or V02, V8-V12, HC	282
114	Tatiana Foroud, PhD	Indiana University	Assessment of CSF and plasma biomarkers of dementia and neurodegeneration in deeply biologically and phenotypically characterized neuronal a-synuclein disease (NSD) and related disorders PPMI cohorts	Expected Q4 2025	NFL and GFAP (plasma); AB40/42 and p-tau 181 in CSF	CSF Plasma	Healthy Control Parkinson Disease Prodromal	N/A	CSF: BL or V02, V8-V12, HC; Plasma: BL or V02, V8-12, V14-V18	283
115	George Tofaris, PhD, MD	University of Oxford	Development of an alpha-synuclein blood biomarker for clinical readiness	Expected Q3 2026	Total aSyn in serum L1CAM-EVs	Serum	Healthy Control Parkinson Disease	LRRK2, GBA, GBA non-manifesting carriers	Baseline	285
116	Erez Eitan, PhD	Neurodex Inc	α-Synuclein in Neuron-Derived Blood Extracellular Vesicles: A Biomarker for the Diagnosis and Staging of Neuronal α-Synuclein Diseases	Expected Q2 2026	aSyn SAA in EVs	Plasma	Healthy Control Parkinson Disease	iPD, HC	N/A	286
117	Jim Eubanks, PhD	Octave Bioscience	Development of a protein biomarker panel to measure Parkinson’s disease activity and progression	Expected Q4 2025	Inflammation, Neurodegeneration	Plasma	Healthy Control Parkinson Disease Prodromal	N/A	BL or V02, V8-12, V14-V18	288
118	Philip Verghese, PhD	C2N Diagnostics	MTBR tau 243 and PrecivityAD2 assays in PPMI Biosamples	Expected Q3 2025	p-tau 243 (CSF) & AB40/42 and p-tau 217 (plasma)	CSF Plasma	Healthy Control Parkinson Disease Prodromal	N/A	CSF: BL or V02, V8-V12, HC; Plasma: BL or V02, V8-12, V14-V18	292
119	Jim Eubanks, PhD	Octave Bioscience	Development of a protein biomarker panel to measure Parkinson’s disease activity and progression	Expected Q4 2025	Targeted proteomics (O-link)	Plasma	Healthy Control Parkinson Disease Prodromal	N/A	BL or V02, V8-12, V14-V18	293
120	Gist Croft, PhD	The New York Stem Cell Foundation	A cohort-wide resource of transcriptomic and morphological phenotypes in defined neural cell types: Environmental Supplement	Expected Q3 2026	Gene expression profiles, morphological features	iPSCs	Healthy Control Parkinson Disease Prodromal	iPD, GBA N370S, LRRK2 G2019S, LRRK2 R1441G, SNCA (A53T), Hyposmic, RBD	N/A	297
121	Silvia Bolgonin, PhD	Maastrict University	NR2F1 role in PD	Expected Q1 2027	NR2F1	iPSCs	Healthy Control Parkinson Disease	LRRK2-G2019S	N/A	298
122	Jennifer Lamoureux, PhD	Amprion	PPMI aSyn SAA Analysis	Expected Q4 2025	Alpha-Synuclein Seeds	CSF	Healthy Control Parkinson Disease Prodromal	N/A	Baseline, 6, 12 Months	299
123	Kim Henriksen, PhD	Nordic Bioscience	alpha-synuclein fragments in serum predict disease progression in Parkinson's Disease	Expected Q3 2025	Calpain-1 generated aSyn fragments (α-syn-C)	Serum	Healthy Control Parkinson Disease	N/A	N/A	300