| 1 | | aaron.fields@ucsf.edu | Yes | Role of cell nutrient supply in disc degeneration | Flexible | Basic Sci; Can be tailored to skill and interest (e.g. MR imaging, biomechanical testing, computer simulation, microscopy) | PI | creativity, attention-to-detail, curiosity | Sampson SL, Sylvia M, Fields AJ. Effects of dynamic loading on solute transport through the human cartilage endplate. J Biomech. 2018 Dec 08. PMID: 30554819 Jung JY, Habib M, Morrissette LJ, Timmons SC, Maerz T, Fields AJ. Non-enzymatic glycation reduces glucose transport in the human cartilage endplate independently of matrix porosity or proteoglycan content. JOR Spine. 2024 Mar; 7(1):e1297. PMID: 38222801 Fields AJ, Han M, Krug R, Lotz JC. Cartilaginous End Plates: Quantitative MR Imaging with Very Short Echo Times-Orientation Dependence and Correlation with Biochemical Composition. Radiology. 2014 Oct 10; 141082. PMID: 25302832 |
| 2 | | aaron.fields@ucsf.edu | Yes | Novel imaging of endplate biomarkers in discogenic low back pain | Flexible | Clinical/Translation | PI | Access to APeX, subject recruitment and consenting, attention-to-detail | Bonnheim NB, Wang L, Lazar AA, Chachad R, Zhou J, Guo X, O'Neill C, Castellanos J, Du J, Jang H, Krug R, Fields AJ. Deep-learning-based biomarker of spinal cartilage endplate health using ultra-short echo time magnetic resonance imaging. Quant Imaging Med Surg. 2023 13(5):2807-2821.PMID: 37179932 Bonnheim NB, Wang L, Lazar AA, Zhou J, Chachad R, Sollmann N, Guo X, Iriondo C, O'Neill C, Lotz JC, Link TM, Krug R, Fields AJ. The contributions of cartilage endplate composition and vertebral bone marrow fat to intervertebral disc degeneration in patients with chronic low back pain. Eur Spine J. 2022 31(7):1866-1872. PMID: 35441890. |
| 3 | | aaron.fields@ucsf.edu | Yes | Spine tissue engineering and regeneration | Flexible | Basic Sci | PI | Basic Wet Lab skills: Cell/Tissue culture preferred | Habib M, Hussein S, Jeon O, Lotz JC, Wu PI, Alsberg E, Fields AJ. Intradiscal treatment of the cartilage endplate for improving solute transport and disc nutrition. Front Bioeng Biotechnol. 2023; 11:1111356. PMID: 36923455 Dolor A, Sampson SL, Lazar AA, Lotz JC, Szoka FC, Fields AJ. Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition. PLoS One. 2019; 14(4):e0215218. PMID: 30970007. |
| 4 | | alan.zhang@ucsf.edu | No | Clinical outcomes for hip arthroscopy surgery. Have prospectively collected patient outcomes data on over 1000 patients who had hip arthroscopy surgery at UCSF. This database can be mined for numerous research topics and studies | Flexible | Sports Medicine and Hip Preservation Surgery Outcomes | PI | Helpful to have: Access to APeX, RedCap use for patient records analysis, basic stats knowledge, manuscript writing | Flores SE, Sheridan JR, Borak KR, Zhang AL. When Do Patients Improve After Hip Arthroscopy for Femoroacetabular Impingement? A Prospective Cohort Analysis. Am J Sports Med. 2018 Nov;46(13):3111-3118. doi: 10.1177/0363546518795696. Epub 2018 Sep 18. PMID: 30226992. |
| 5 | | brian.feeley@ucsf.edu | Yes | Evaluation of muscle stem cell quality in rotator cuff and other muscle injury models | Flexible | Translation Research | Postdoc/PI | Histology, PCR, Cell Culture. Additional skills in genomic analysis, animal surgery, will be taught | 1: Davies MR, Garcia S, Tamaki S, Liu X, Lee S, Jose A, Pomerantz JH, Feeley BT.
Muscle stem cell activation in a mouse model of rotator cuff injury. J Orthop
Res. 2018 May;36(5):1370-1376. doi: 10.1002/jor.23679. Epub 2018 Mar 9. PubMed
PMID: 28786534; PubMed Central PMCID: PMC5803476.
2: Liu X, Ning AY, Chang NC, Kim H, Nissenson R, Wang L, Feeley BT. Investigating
the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after
injury. Muscles Ligaments Tendons J. 2016 May 19;6(1):6-15. doi:
10.11138/mltj/2016.6.1.006. eCollection 2016 Jan-Mar. PubMed PMID: 27331027;
PubMed Central PMCID: PMC4915463.
3: Davies MR, Liu X, Lee L, Laron D, Ning AY, Kim HT, Feeley BT. TGF-β Small
Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty
Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis. PLoS One. 2016
May 17;11(5):e0155486. doi: 10.1371/journal.pone.0155486. eCollection 2016.
PubMed PMID: 27186977; PubMed Central PMCID: PMC4871364.
4: Liu M, Lee C, Laron D, Zhang N, Waldorff EI, Ryaby JT, Feeley B, Liu X. Role
of pulsed electromagnetic fields (PEMF) on tenocytes and myoblasts-potential
application for treating rotator cuff tears. J Orthop Res. 2017
May;35(5):956-964. doi: 10.1002/jor.23278. Epub 2017 Apr 7. PubMed PMID:
27138553.
5: Laron D, Samagh SP, Liu X, Kim HT, Feeley BT. Muscle degeneration in rotator
cuff tears. J Shoulder Elbow Surg. 2012 Feb;21(2):164-74. doi:
10.1016/j.jse.2011.09.027. Review. PubMed PMID: 22244059. |
| 6 | | meir.marmor@ucsf.edu | Yes | Prospective collection of biometrics in response to administration of pain medication after surgery | Year-round | Post operative pain alleviation | PI | Patient interaction, chart review, data collection | |
| 7 | | meir.marmor@ucsf.edu | Yes | Using wearable device data to determine methods for post-operative pain alleviation and pain management. The project has various sub-projects involving clinical testing and data sci | Year-round | Data Sci, Clinical Research | PI | Experience working with R or similar data processing language, patient interaction, chart review | |
| 8 | | meir.marmor@ucsf.edu | Yes | Development of an ultrasound-based method of diagnosing Acute Compartment Syndrome and muscle injury/health. The project has various sub-projects involving in-vitro testing, cadaveric testing, and clinical testing | Year-round | Acute Compartment Syndrome, Clinical Research | PI | Experience working with R or similar data processing language, patient interaction, chart review | |
| 9 | | meir.marmor@ucsf.edu | Yes | Single-camera motion analysis of orthopaedic surgery outcomes and clinical practice. The project involves the collection of camera footage in the operation room and clinic space and the application of advanced image analysis techniques | Year-round | Image Analysis | PI | Ability to use image analysis software, patient interaction | |
| 10 | | meir.marmor@ucsf.edu | Yes | Geriatric fracture biomechanics & outcomes | Year-round | Biomechanical research, data science | PI | interest in biomechanical testing, data analysis | |
| 11 | | meir.marmor@ucsf.edu | No | Social Health Determinants in Orthopaedic Trauma | Year-round | Data Science | PI | interest in social issues of health, data analysis | |
| 12 | | meir.marmor@ucsf.edu | No | Digital solutions to management of problematic tibia fractures - 3D printing & computer simulation | Year-round | 3D printing, computer science | PI | 3D printing experience, modeling experience | |
| 13 | | sigurd.berven@ucsf.edu | Yes | Predictive modeling of outcomes and complications in spine surgery using computational health and large database research | Flexible | Clinical Outcomes in Spine Surgery | PI | Enthusiasm for clinical research and data review | Clinical outcomes and complications after surgery for degenerative scoliosis. Spine 2016 |
| 14 | | tamara.alliston@ucsf.edu | Yes | Cellular Dysfunction in Arthritis and Osteoporosis | Flexible | Histological Analysis of Existing Sections using established protocols -- mouse or human arthritis or bone fragility | Staff | Curiosity. Project can be tailored to skill and interest -- Computational, microscopy and/or histology | Dole, et al...Alliston, Cell Reports 2017;
Fowler et al...Alliston, Scientific Reports 2017 |
| 15 | | OandPResearch@ucsf.edu | Pending | Proximal Junctional Kyphosis Rates after the Introduction of the UCSF Soft TLSO: A Retrospective Study | 1 year | | Staff | | |
| 16 | | OandPResearch@ucsf.edu | Yes | Empirical Measurement of Dosing Efficacy in Pectus Carinatum Bracing: A Prospective Cohort Study | >1 year | | Staff | | Jung J., Chung S.H., Cho J.K., Park S., Choi H., Lee S. (2012) Brace Compression for Treatment of Pectus Carinatum. Korean J Thorac Cardiovasc Surg. 45(6): 396-400.
Kang D., Jung J., Chung S., Cho J., Lee S. (2014) Factors affecting patient compliance with compressive bracing for pectus carinatum. Interactive Cardiovascular and Thoracic Surgery. 19(6): 900-903.
FokinA., Steuerwald N., Ahrens W., Allen K. (2009) Anatomical, histologic, and genetic characteristics of congenital chest wall deformities. Semin Thorac Cardiovasc Surg. 21:44-57 |