CHOP Research Vector Core Service List

	Updated on July 2025	--	---	-----	------	-------
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2	Recombinant Adeno-Associated Virus (rAAV)
3	Vector Production Services *	Surface Area (sq.cm)	CHOP & UPenn Rate	Academic Rate	Industry Rate	Endotoxin-free Plasmid Required
4	Inventory Order (aliquots of 50ul or 100ul)	NA	$400.00	$440.00	$520.00	NA
5	Inventory Order (rAAV serotype screening kit***)	NA	$1,200.00	$1,320.00	$520.00	NA
6	Screening Scale **	850	$1,400	$1,540.00	$1,820.00	0.2mg
7	Pilot Scale **	1,700	$2,800	$3,080.00	$3,640.00	0.5mg
8	Small Scale	4,250	$4,200.00	$4,620.00	$5,460.00	1.0 mg
9	Regular Scale	8,500	$6,300.00	$6,930.00	$8,190.00	2.0 mg
10	Large Scale	21,250	$14,000.00	$15,400.00	$18,200.00	4.0 mg
11	Mega Scale	34,000	$19,000.00	$20,900.00	$24,700.00	6.0 mg
12	Customized Scale	TBD	TBD	TBD	TBD	TBD
13	Customized Vector Finish and Fill	TBD	TBD	TBD	TBD	TBD
14	* Cost includes particle titer by UV/Vis/DLS/SLS
15	** Simplified purification process with one round of CsCl centrifugation
16	** 9 rAAV-eGFP vectors with AAV1, 2, 3, 5, 6, 8, 9, and PHP.eB for serotype testing
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18	Recombinant Lentivirus (rLV)
19	Vector Production Services ^	Surface Area (sq.cm)	CHOP & UPenn Rate	Academic Rate	Industry Rate	Endotoxin-free Plasmid Required
20	Inventory Order (aliquots of 50ul or 100ul)	NA	$400.00	$440.00	$520	NA
21	Pilot Scale (Centrifugation)	450	$1,200.00	$1,320.00	$1,560	0.1 mg
22	Regular Scale (Sucrose Gradient)	2,544	$3,600.00	$3,960.00	$4,680	0.3 mg
23	Process Scale (GLP-like process)	7,632	$13,000.00	$14,300.00	$16,900	1.5 mg
24	Customized Scale **	TBD	TBD	TBD	TBD	TBD
25	Customized Vector Finish and Fill	TBD	TBD	TBD	TBD	TBD
26	^ VSVG pseudotyped with 3rd generation packaging system
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28	Supportive Services
29	Viral Vector Quality Control		CHOP & UPenn Rate	Academic Rate	Industry Rate
30	AAV Purity Check by SDS-PAGE and Silver Stain		$1,200	$1,320	$1,560
31	AAV Purity Check by SDS-PAGE and Coomassie Stain		$500	$550	$650
32	AAV Genome Titer by ddPCR (transgene-specific)		$800	$880	$1,040
33	AAV Genome Titer by ddPCR (ITR)		$600	$660	$780
34	AAV Particle Titer by UV-VIS/DLS/SLS		$400	$440	$520
35	AAV Empty and Full Assessment by UV-VIS/DLS/SLS		$500	$550	$650
36	AAV Genome Integrity Check by Alkaline Agarose Gel		$800	$880	$1,040
37	AAV Cesium level by Osmolality		$600	$660	$780
38	Endotoxin test		$600	$660	$780
39	Bioburden test		$400	$440	$520
40	Mycoplasma test		$600	$660	$780
41	LVV Particle Titer by P24 ELISA		$1,200	$1,320	$1,560
42	LVV Particle Titer by qRT-PCR		$800	$880	$1,040
43	LVV Transduction Titer on HEK293 by Flow Cytometry		$700	$770	$910
44	LVV Transduction Titer on HEK293 by ddPCR		$800	$880	$1,040
45	DNA Vector Cloning Amplification and QC		CHOP & UPenn Rate	Academic Rate	Industry Rate
46	Cloning and Full Sequence Confirmation		TBD	TBD	TBD
47	Plasmid Amplification (Endotoxin-free Mega)		$400	$440	$520
48	Plasmid Amplification (Endotoxin-free Giga)		$800	$880	$1,040
49	Sequence and Structure analysis by RE digestion		$200	$220	$260
50	Sequence Confirmation of Whole Construct		$800	$880	$1,040
51	Special Request on Vector Finish and Fill		TBD	TBD	TBD
52	Shipping & Handling (via FedEx Express)		CHOP & UPenn Rate	Academic Rate	Industry Rate
53	Handling only (packaging and dry ice)		$50	$55	$65
54	US Shipping		$200	$220	$260
55	International Shipping		TBD	TBD	TBD
56	Consultation and CMC support		CHOP & UPenn Rate	Academic Rate	Industry Rate
57	Hourly based		$200	$220	$260
58	Project-based		TBD	TBD	TBD
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