RVC Price
Service and ScaleYieldAt Cost ***EndoFree Plasmid Plasmid
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rAAV Production (FY22)
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Service and Scale
Yield *At Cost ***EndoFree Plasmid Plasmid
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Inventory Order (aliquots of 50ul or 100ul)
1E11 - 1E12 GC$275.00NA
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Pilot
1E12 - 5E12 GC$2,200.000.3 mg
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Small
6E12 - 1E13 GC$3,800.001.0 mg
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Regular **
1E13 - 2E13 GC$5,500.002.0 mg
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Large **
3E13 - 5E13 GC$9,500.005.0 mg
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Mega **
6E13 - 1E14 GC$20,000.0010.0 mg
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*The estimated yields are based on historic data. Due to the nature of individual, transgene constructs, the yield is varied, and therefore is not guaranteed.
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**A minimum titer of 1E+13 vg/ml can be achieved based on packaging efficiency of the transgene, which can result in lower volume.
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*** Hosptial surchage will be added for non CHOP/Penn clients, at 10% Academic Rate and 30% Industry Rate
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Service and Scale
ProcessAt Cost **EndoFree Plasmid Plasmid
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rLV Production (FY22)
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Production Scale
ProcessAt Cost *EndoFree Plasmid Required
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Inventory order (Mini Aliquot)
$275.00NA
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Custom rLV Production - Pilot Scale
Centrifugation$700.000.1 mg
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Custom rLV Production - Regular Scale
Sucrose Gradient$3,000.000.3 mg
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Custom rLV Production - Process Scale
GLP like process$7,500.001.5 mg
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* Hosptial surchage will be added for non CHOP/Penn clients, at 10% Academic Rate and 30% Industry Rate
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QC Supportive Service Core FY19
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Quality Contol Assay
At Cost *
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Particle titer and Purity Check by Silver Stain (AAV)
600
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Genome titer by qPCR (AAV)
600
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Genome titer by ddPCR (AAV)
600
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P24 ELISA (LVV)
600
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HEK293 Transduction titer by Flow Cytometry (LVV)
400
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HEK293 Transduction titer by ddPCR (LVV)
600
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Endotoxin test by Endosafe® nexgen-PTS™
300
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Bioburden test
200
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Mycoplasma test
300
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Cesium level by Osmolality
400
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Supportive Service
At Cost *
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Cloning and Full Sequence Confirmation
1,500.00
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Plasmid Amplification (Endotoxin-free Mega)
450.00
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Plasmid Amplification (Endotoxin-free Giga)
700.00
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Sequence and Structure analysis by RE digestion
200
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Sequence Confirmation of whole construct
800
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Special Request on Vector Finish and Fill
Customized
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Shipping & Handling (via FedEx Express)
At Cost *
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Shipping charge - US East coast
250
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Shipping charge - US west coast
300
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Shipping charge - international
Variable **
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Consultation Charges
TBD by projects
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* Hosptial surchage will be added for non CHOP/Penn clients, at 10% Academic Rate and 30% Industry Rate.
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** Shipping charge is based on the cost from shipping core.
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Concentrated and purified Lentiviral vector (VSVG psedotyped) will be manufactured at Research Grade. The estimated yields are based on historic data and packaging efficiency.Due to the nature of individual trangene constructs, yields vary and therefore titer is not guaranteed.