| 1 | | aaron.fields@ucsf.edu | Yes | Role of celle nutrient supply in disc degeneration | Flexible | basic science; can be tailored to skill and interest, e.g. MR imaging, biomechanical testing, computer simulation, microscopy | PI | creativity, attention-to-detail, curiosity, | Sampson SL, Sylvia M, Fields AJ. Effects of dynamic loading on solute transport through the human cartilage endplate. J Biomech. 2018 Dec 08. PMID: 30554819
Fields AJ, Han M, Krug R, Lotz JC. Cartilaginous End Plates: Quantitative MR Imaging with Very Short Echo Times-Orientation Dependence and Correlation with Biochemical Composition. Radiology. 2014 Oct 10; 141082. PMID: 25302832 | | |
| 2 | | aaron.fields@ucsf.edu | Yes | Novel imaging of endplate biomarkers in discogenic low back pain | Flexible | access to APeX, subject recruitment and consenting, attention-to-detail | PI | | | | |
| 3 | | aaron.fields@ucsf.edu | Yes | Spine tissue engineering and regeneration | Flexible | basic science | PI | basic wet lab skills: cell/tissue culture preferred | Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition. PLoS One. 2019; 14(4):e0215218. Dolor A, Sampson SL, Lazar AA, Lotz JC, Szoka FC, Fields AJ. PMID: 30970007; PMCID: PMC6457523.; | | |
| 4 | | alan.zhang@ucsf.edu | No | Clinical outcomes for hip arthroscopy surgery. We have prospectively collected patient outcomes data on over 1000 patients who had hip arthroscopy surgery at UCSF. This database can be mined for numerous research topics and studies. | Flexible | Sports medicine and hip preservation surgery outcomes | PI | Helpful to have: access to APEX, RedCap use for patient records analysis, basic Stats knowledge, manuscript writing | Flores SE, Sheridan JR, Borak KR, Zhang AL. When Do Patients Improve After Hip Arthroscopy for Femoroacetabular Impingement? A Prospective Cohort Analysis. Am J Sports Med. 2018 Nov;46(13):3111-3118. doi: 10.1177/0363546518795696. Epub 2018 Sep 18. PMID: 30226992. | | |
| 5 | | brian.feeley@ucsf.edu | Yes | Evaluation of muscle stem cells in rotator cuff and other muscle injury models | Flexible | translational research | Postdoc | Histology, PCR are highly recommended. Additional skills in genomic analysis, animal surgery, will be taught | The Feeley-Liu Muscle Stem Cell Lab had eight presentations at the Orthopedic Research Society Annual Meeting in New Orleans, 2018. There were a variety of presentations on the role of muscle stem cells in the outcome of different muscle injuries including rotator cuff injuries, direct muscle injury, and reperfusion injury.
Mengyao Liu, Xuhui Liu, Zili Wang, Lawrence Lee, Michael Davies, Hubert Kim, Brian T. Feeley
Histone Deacetylase Inhibitor Trichostatin A Reduces FAP Adipogenesis and Muscle Fatty Infiltration.
Poster presentation at the ORS Annual Meeting 2018, New Orleans, LA
Mengyao Liu, Brian Feeley, Hubert Kim, Xuhui Liu
The Effects of Macrophages on FibroadipogenicProgenitors (FAPs) Adipogenesis.
Poster presentation at the ORS Annual Meeting 2018, New Orleans, LA
Mengyao Liu, Brian Feeley, Zili Wang, Hubert Kim, Xuhui Liu.
MMP-13 Inhibits Adipogenesis of Muscle Fibroadipogenic Progenitors (FAPs)
Poster presentation at the ORS Annual Meeting 2018, New Orleans, LA
Zili Wang, Michael R. Davies, Mengyao Liu, Devante Horne, Jeffrey Lotz, Hubert Kim, Xuhui Liu, Brian T. Feeley
Delayed Repair of Rotator Cuff Tears Results in ReducedFatty Infiltration and Improved Shoulder Function in Mice
Poster presentation at the ORS Annual Meeting 2018, New Orleans, LA
Obiajulu Agha, Khalid Al-rayess, Mengyao Liu, Audrey Lukawski, Zili Wang, Xuhui Liu, Brian Feeley
Human Satellite Cell Transplantation in Volumetric Injury Model Results in Improved Markers of Muscle Quality
Poster presentation at the ORS Annual Meeting 2018, New Orleans, LA
Obiajulu Agha, Khalid Al-rayess, Mengyao Liu, Audrey Lukawski, Zili Wang, Xuhui Liu, Brian Feeley
Human Fibro-Adipogenic Progenitor (FAP) Cells Undergo Myotube Formation in Osteogenic Conditions In Vitro
Poster presentation at the ORS Annual Meeting 2018, New Orleans, LA
Chantal Nguyen, Zili Wang, Lawrence Lee, Mengyao Liu, Shingo Kajimura, Hubert Kim, Brian Feeley, Xuhui Liu
Activation of Brown/Beige Fat Regulates Muscle Regeneration After Ischemia-Reperfusion Injury
Oral presentation at the ORS Annual Meeting 2018, New Orleans, LA
Zili Wang, Mengyao Liu, Lawrence Lee, Hubert Kim,Brian Feeley, Xuhui Liu
Release of Chronic Suprascapular Nerve Compression Reverses Muscle Fatty Infiltration in Mice
Oral presentation at the ORS Annual Meeting 2018, New Orleans, LA | | |
| 6 | | brian.feeley@ucsf.edu | Yes | Evaluation of human rotator cuff tissue and muscle stem cell quality | Flexible | Translational Research | PI | histology, PCR, cell culture | 1: Davies MR, Garcia S, Tamaki S, Liu X, Lee S, Jose A, Pomerantz JH, Feeley BT.
Muscle stem cell activation in a mouse model of rotator cuff injury. J Orthop
Res. 2018 May;36(5):1370-1376. doi: 10.1002/jor.23679. Epub 2018 Mar 9. PubMed
PMID: 28786534; PubMed Central PMCID: PMC5803476.
2: Liu X, Ning AY, Chang NC, Kim H, Nissenson R, Wang L, Feeley BT. Investigating
the cellular origin of rotator cuff muscle fatty infiltration and fibrosis after
injury. Muscles Ligaments Tendons J. 2016 May 19;6(1):6-15. doi:
10.11138/mltj/2016.6.1.006. eCollection 2016 Jan-Mar. PubMed PMID: 27331027;
PubMed Central PMCID: PMC4915463.
3: Davies MR, Liu X, Lee L, Laron D, Ning AY, Kim HT, Feeley BT. TGF-β Small
Molecule Inhibitor SB431542 Reduces Rotator Cuff Muscle Fibrosis and Fatty
Infiltration By Promoting Fibro/Adipogenic Progenitor Apoptosis. PLoS One. 2016
May 17;11(5):e0155486. doi: 10.1371/journal.pone.0155486. eCollection 2016.
PubMed PMID: 27186977; PubMed Central PMCID: PMC4871364.
4: Liu M, Lee C, Laron D, Zhang N, Waldorff EI, Ryaby JT, Feeley B, Liu X. Role
of pulsed electromagnetic fields (PEMF) on tenocytes and myoblasts-potential
application for treating rotator cuff tears. J Orthop Res. 2017
May;35(5):956-964. doi: 10.1002/jor.23278. Epub 2017 Apr 7. PubMed PMID:
27138553.
5: Laron D, Samagh SP, Liu X, Kim HT, Feeley BT. Muscle degeneration in rotator
cuff tears. J Shoulder Elbow Surg. 2012 Feb;21(2):164-74. doi:
10.1016/j.jse.2011.09.027. Review. PubMed PMID: 22244059. | | |
| 7 | | OandPResearch@ucsf.edu | Pending | Proximal Junctional Kyphosis Rates after the Introduction of the UCSF Soft TLSO: A Retrospective Study | 1 year | | Staff | | | | |
| 8 | | oandpresearch@ucsf.edu | Yes | Empirical Measurement of Dosing Efficacy in Pectus Carinatum Bracing: A Prospective Cohort Study | >1 year | | Staff | | Jung J., Chung S.H., Cho J.K., Park S., Choi H., Lee S. (2012) Brace Compression for Treatment of Pectus Carinatum. Korean J Thorac Cardiovasc Surg. 45(6): 396-400.
Kang D., Jung J., Chung S., Cho J., Lee S. (2014) Factors affecting patient compliance with compressive bracing for pectus carinatum. Interactive Cardiovascular and Thoracic Surgery. 19(6): 900-903.
FokinA., Steuerwald N., Ahrens W., Allen K. (2009) Anatomical, histologic, and genetic characteristics of congenital chest wall deformities. Semin Thorac Cardiovasc Surg. 21:44-57 | | |
| 9 | | meir.marmor@ucsf.edu | Yes | Prospective collection of ultrasound based measurements of injured limbs for the purpose of building a diagnostic database of images that will help in the diagnosis of acute compartment syndrome | 12 months | Acute Compartment Syndrome | PI | Patient interaction, chart review, data collection | | | |
| 10 | | meir.marmor@ucsf.edu | No | Prospective collection of video based measurements of injured limbs for the purpose of building a diagnostic database of images that will help in the diagnosis of acute compartment syndrome | 12 months | Acute Compartment Syndrome | PI | Patient interaction, chart review, data collection | | | |
| 11 | | meir.marmor@ucsf.edu | Yes | Prospective collection of biometrics in response to administration of pain medications after surgery | 2-6 months | Post operatve pain alleviation | PI | Patient interaction, chart review, data collection | | | |
| 12 | | Sigurd.Berven@ucsf.edu | Yes | Predictive modelling of outcomes and complications in spine surgery using computational health and large database research. | Flexible | Clinical outcomes in spine surgery | PI | Enthusiasm for clinical research and data review | Clinical outcomes and complications after surgery for degenerative scoliosis. Spine 2016 | | |
| 13 | | tamara.alliston@ucsf.edu | Yes | Cellular Dysfunction in Arthritis and Osteoporosis | Flexible | histological analysis of existing sections using established protocols - mouse or human arthritis or bone fragility | Staff | Curiosity. Project can be tailored to skill and interest - computational, microscopy and/or histology | Dole, et al...Alliston, Cell Reports 2017;
Fowler et al...Alliston, Scientific Reports 2017 | | |